Toranomon Nakamura Clinic Medication Prescription Site

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. Ketosis, diabetic coma or precoma, type 1 diabetes, severe infection, pre- and post-surgery, injured, renal disorder, pituitary gland abnormality, adrenal disease, inadequate food intake, debilitated , exercising vigorously, drinking a lot of alcohol.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 1 tablet (100 mg of trelagliptin) at a time, once a week on the decided day of the week. In patients with moderate or severe renal impairment, the dosage may be reduced according to the degree of renal function. Be sure to follow the directions for use.
• If you miss a dose, take the prescribed dose when you remember and take the next dose on the prescribed day of the week. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions in daily life

• Please follow the prescribed diet and exercise regimen. This medicine may cause hypoglycemia. Pay close attention when you work at heights or operate dangerous machinery such as driving a car. Also, inform your family and people around you that you are taking this medicine.
• If hypoglycemic symptoms occur, take a sufficient amount of sugar (sugar, glucose, soft drinks, etc.). If you are taking this medicine concurrently with an α -glucosidase inhibitor (drugs that delay the absorption of sugar such as voglibose and acarbose), take glucose when hypoglycemic symptoms occur.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include nasopharyngitis, rash and itch. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• cold sweat, hunger, trembling of limbs [hypoglycemia]
• blister, erosion, red rash [pemphigoid]
• abdominal pain, vomiting [acute pancreatitis]
• constipation, abdominal bloating, abdominal pain, vomiting [intestinal obstruction]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have gastrointestinal disorders such as type 1 diabetes or gastroparesis. If you have a history of pancreatitis. If you have ever had a gastrectomy.
• Pregnant, possibly pregnant, planning to become pregnant within the next 2 months, or breastfeeding.

Dosage and administration (how to use this medicine)

• Take 3 mg once daily for 10 days, then 7 mg once daily for 10 days, then 14 mg once daily for 100 days. Be sure to follow the directions for use.
• Take on an empty stomach before the first meal or water of the day.
• Take 1 tablet with about half a glass of water (about 120 mL or less). Do not take 2 tablets.
• Avoid eating, drinking and taking other medicines for at least 30 minutes after taking this medicine.
• Do not split, crush, or chew this medicine.
• This medicine is highly hygroscopic, so take it out of the PTP sheet immediately before taking it.
• Since the PTP packaging sheet is moisture-proof, do not separate it at any place other than the perforations.
• If you miss a dose, skip the missed dose on that day and take a dose on the next day. Never take two doses at once.

Precautions in daily life

• Hypoglycemia may occur. Be careful when engaging in dangerous work such as working at heights or driving a car. Inform your family and friends about hypoglycemia. If symptoms of hypoglycemia appear, take foods containing carbohydrates immediately.
• Acute pancreatitis may occur. If persistent severe abdominal pain with vomiting occurs, discontinue use and promptly consult a doctor.
• If you experience thyroid-related symptoms (a hard lump when you touch your neck, etc.), you may need to see a specialist, so please consult your doctor.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include nausea, diarrhea, decreased appetite, headache, diabetic retinopathy, constipation and vomiting. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• hunger, cold sweat, chills, fatigue easily, tremor of limbs, convulsion, decreased consciousness [hypoglycemia]
• nausea, vomiting, severe epigastric pain, back pain, bruise on the stomach, swelling [acute pancreatitis]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store at room temperature (1 to 30°C) without removing from the PTP sheet as it is highly hygroscopic and unstable to light .
• Discard any remaining medicine. Please consult the pharmacy or medical institution where you received the product regarding disposal.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have ketosis, diabetic coma or precoma, infection, before or after surgery, or trauma.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 1 tablet (100 mg of canagliflozin) at a time, once a day, before or after breakfast. Be sure to follow the directions for use.
• If you miss a dose, skip the missed dose and continue your regular dosing schedule. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions in daily life

• Please follow the prescribed diet and exercise regimen.
• This medicine may cause hypoglycemic symptoms. Pay attention when working at heights or operating dangerous machinery such as driving a car.
• If hypoglycemic symptoms occur, take a sufficient amount of sugar (sugar, glucose, soft drinks, etc.). If you are taking this medicine concurrently with α -glucosidase inhibitors (drugs that delay the absorption of sugar), take glucose when hypoglycemic symptoms occur.
• As symptoms of dehydration may occur, try to drink plenty of water.
• Ketoacidosis may occur even without hyperglycemia, so if you feel any symptoms of ketoacidosis, immediately consult a doctor.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include hypoglycemia, frequent urination and constipation. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• cold sweat, hunger, trembling of limbs [hypoglycemia]
• thirst, malaise, dizziness [dehydration]
• nausea/vomiting, deep breathing, decreased consciousness/judgment [ketoacidosis]
• chills, fever, flank/back pain [pyelonephritis, sepsis]
• fever, swelling/pain/redness in the genital area [necrotizing fasciitis of the genital area (Fournier's gangrene)]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have renal disorder.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 1.5 to 3 g of the active ingredient daily in 3 divided doses. It will be increased or decreased depending on the situation. This drug contains 100mg of the active ingredient in 1 tablet. Be sure to follow the directions for use.
• If you miss a dose, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include loss of appetite, diarrhea, loose stools, abdominal bloating, facial edema, hematuria and anemia. If you notice any of these symptoms, consult your doctor or pharmacist.
The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have renal disorder.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 1.5 to 3 g of the active ingredient daily in 3 divided doses. It will be increased or decreased depending on the situation. This drug contains 100mg of the active ingredient in 1 tablet. Be sure to follow the directions for use.
• If you miss a dose, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include loss of appetite, diarrhea, loose stools, abdominal bloating, facial edema, hematuria and anemia. If you notice any of these symptoms, consult your doctor or pharmacist.
The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have diabetic ketoacidosis, diabetic coma or precoma, or type 1 diabetes. For emergencies such as severe infections and surgery. If you have a pituitary gland disorder, adrenal disease, do not eat enough, are weak, exercise vigorously, drink a lot of alcohol, or have pancreatitis.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• The usual adult dosage is 0.5 mg once a week by subcutaneous injection. However, start with 0.25 mg once a week and increase to 0.5 mg once a week after 4 weeks of injection. The injection dose may be adjusted according to the condition. However, if the effect is insufficient even after injecting 0.5 mg once a week for 4 weeks or longer, the dose may be increased up to 1.0 mg once a week. Always follow the instructions for use.
• Inject once a week on the same day of the week.
• should be 2-3 cm away from the previous injection site.
• If you miss an injection and there is more than 2 days (48 hours) until the next scheduled injection date, inject as soon as you remember, and then inject on the prescribed day of the week. If the period until the next scheduled injection date is less than 2 days (48 hours), do not inject and inject on the next predetermined day of the week. Never inject two doses at once.
• If you accidentally inject too much, consult your doctor or pharmacist immediately.
• Do not stop the injection on your own without your doctor's instructions.

Precautions in daily life

• Please follow the prescribed diet and exercise regimen.
• Pay attention when working at heights or operating dangerous machinery such as driving a car.
• After getting family members and people around you to understand how to inject and how to deal with hypoglycemia symptoms, when hypoglycemia symptoms occur, take a sufficient amount of sugar (sugar, glucose, soft drinks, etc.) Please take
• Acute pancreatitis may occur. If persistent severe abdominal pain with vomiting occurs, discontinue use and promptly consult a doctor.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include nausea, diarrhea and constipation. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• weakness/malaise, severe hunger, cold sweat [hypoglycemia]
• sudden severe pain in the abdomen or lower back, fever, nausea/vomiting [acute pancreatitis]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Keep out of reach of infants and children, avoiding light. Avoid freezing unused products and store them in the refrigerator (2-8°C). Store in use at room temperature (including refrigerator (2-8°C)) and use within 8 weeks.
• If you have leftover medicine, do not store it and throw it away. Please consult the pharmacy or medical institution where you received the product regarding disposal.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• The following people may need attention. Be sure to tell your doctor or pharmacist. If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have gastrointestinal disorder such as type 1 diabetes, diabetic gastroparesis or inflammatory bowel disease. If you have a history of abdominal surgery, intestinal obstruction, or pancreatitis.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, inject 0.9 mg once a day in the morning or evening. Start with 0.3 mg once a day, and increase by 0.3 mg at intervals of 1 week or more. The injection time can be in the morning or evening, but should be injected at the same time as much as possible. The injection dose may be adjusted according to the patient's condition. If 0.9 mg/day is insufficient, the dose may be increased by 0.3 mg at intervals of 1 week or longer, up to a maximum of 1.8 mg. Always follow the instructions for use.
• should be 2-3 cm away from the previous injection site.
• Be sure to read the attached instruction manual before starting the injection.
• If you miss an injection, consult your doctor. Never inject two doses at once.
• If you accidentally inject too much, consult your doctor or pharmacist immediately.

Precautions in daily life

• Please follow the prescribed diet and exercise regimen.
• This medicine may cause hypoglycemic symptoms, so be careful when working at heights, driving a car, or performing other dangerous tasks.
• Make sure that not only the patient but also their families and people around them understand the injection method and how to deal with hypoglycemia, and that they should eat foods containing carbohydrates when hypoglycemia occurs.
• Acute pancreatitis may occur. If persistent severe abdominal pain with vomiting occurs, discontinue use and promptly consult a doctor.
• If you experience thyroid-related symptoms (a hard lump when you touch your neck, etc.), consult the doctor who prescribed this medicine and receive instructions about seeing a specialist.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include constipation and nausea. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• hunger, cold sweat, chills, fatigue easily, tremor of limbs, convulsion, decreased consciousness [hypoglycemia]
• severe abdominal pain, back pain, bloating, nausea, vomiting, weight loss, thirst, increased urine output, yellow skin, oily diarrhea [pancreatitis ]
• difficulty passing stool or fart, nausea, vomiting, decreased stomach, abdominal pain [intestinal obstruction]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Keep out of reach of infants and children, avoiding light. Avoid freezing before use, and store cleanly in a refrigerator (2-8°C). After starting use, do not refrigerate, cover with a cap, etc. to avoid light, store at room temperature, and use within 30 days.
• Discard any remaining medicine. Please consult the pharmacy or medical institution where you received the product regarding disposal.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have a malignant tumor. Prader-Willi syndrome with obesity or respiratory problems. If you have diabetes, impaired glucose tolerance, or risk factors for diabetes. have heart disease. If you have a brain tumor (craniopharyngioma, pituitary adenoma, pinealoma, etc.). If you have a history of brain tumor. If you have chronic renal failure or renal disease.

Dosage and administration (how to use this medicine)

• The usual starting dose is 0.021 mg of the active ingredient per kilogram of body weight per week, subcutaneously injected in 6 to 7 divided doses. The dosage should be gradually increased up to 0.084 mg/kg body weight per week according to clinical symptoms, and injected subcutaneously in 6 to 7 divided doses per week. The injection dose may be adjusted according to clinical symptoms and laboratory findings such as serum insulin-like growth factor-I (IGF-I) concentration, but the daily dose should not exceed 1 mg. This drug contains 12.0mg of the main ingredient in one cartridge. Be sure to follow the indicated method.
• Change the injection site each time.
• Use a dedicated A-type (type) injection needle that conforms to JIS T 3226-2.
• If you forget to take an injection, inject the dose when you remember. Do not inject two doses at once.
• If you accidentally inject too much, your blood sugar will first drop (hungry, cold sweats, chills, tiredness, tremors in your hands and feet, convulsions, loss of consciousness), followed by an increase in blood sugar (feeling tired, losing weight, etc.). Thirst, drinking a lot of water, increased urine output) may occur. In addition, long-term excessive use may cause acromegaly symptoms (forehead, nose, chin, extremities of the body such as hands and feet become enlarged, etc.). If you have these symptoms, please contact your doctor immediately.

Precautions in daily life

• HbA1c, etc. should be checked regularly . People with diabetes are also regularly checked for conditions associated with diabetes, such as diabetic retinopathy. If you experience symptoms such as decreased visual acuity, narrowing of the field of vision, parts that cannot be seen in the field of vision, or distorted objects, consult a doctor.
• You may have regular thyroid function tests. Appropriate treatment should be given if hypothyroidism (easily tired, swollen eyelids, sensitivity to cold, weight gain, sleepiness, constipation, hoarseness, hair loss) appears or worsens.
• If you have had a brain tumor in the past, you should have regular imaging tests because the use of this drug may cause the brain tumor to recur.
• If you experience edema (weight gain, body swelling, puffy eyes), joint pain (joint pain, difficulty in moving joints due to pain), etc., due to the use of this medicine, consult your doctor.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include edema, emotional instability, joint pain, muscle weakness, abnormal thinking and hematuria. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• spasmodic muscle contraction [convulsion]
• sweating, weight loss, increased pulse rate [hyperthyroidism]
• marked swelling of the whole body, decreased urine output, respiratory distress [nephrotic syndrome]
• dry mouth, drinking a lot of water, getting tired easily [diabetes mellitus]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• After thawing, avoid freezing, store at 2-8°C from light, and use within 4 weeks. Do not use if frozen after thawing.
• If you have leftover medicine, do not store it and throw it away. If you do not know how to dispose of it, please consult the pharmacy or medical institution where you received it. Do not give it to others.
• Place used needles and this product in the dedicated trash can and dispose of it according to the instructions of the medical institution.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. Cardiovascular disorders, liver dysfunction, hypotension or hypertension, retinitis pigmentosa, sickle cell anemia, multiple myeloma, leukemia, bleeding disorders or peptic ulcers, renal disorders, multiple system atrophy ( Shy- Drager syndrome, etc.), structural defects in the penis (flexion, etc.), cerebral infarction, cerebral hemorrhage, or myocardial infarction within the last 6 months.
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 25 to 50 mg of sildenafil at a time, once a day about 1 hour before sexual activity. Elderly people (65 years old or older) and patients with liver disorder or severe renal disorder should start taking 25 mg at a time. This drug contains 50mg of sildenafil per tablet. Be sure to follow the directions for use.
• Take once a day, and wait at least 24 hours before taking the next dose. Never take two doses at once.
• Taking this medicine with food may affect the effect.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine without your doctor's advice.

Precautions in daily life

• Sexual activity puts a strain on the heart. Don't overdo it. Also, sexually transmitted diseases cannot be prevented.
• This medicine may cause dizziness or visual disturbance (color changes, etc.). Pay close attention when driving a car or operating machinery.
• If you experience symptoms such as a sudden decrease in vision or loss of vision, stop taking this medicine and consult an ophthalmologist immediately.
• Please tell your partner that you are taking (or are taking) this medicine.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include vasodilation (hot flash, flushing), headache, indigestion and palpitation. If you notice any of these symptoms, consult your doctor or pharmacist.
The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store at room temperature (1 to 30°C), away from direct sunlight and moisture, out of reach of infants and children .
• If you have leftover medicine, do not store it and throw it away. If you do not know how to dispose of it, please consult the pharmacy or medical institution where you received it. Do not give it to others.

I fully understand the above effects and side effects. Do not take orally other than the prescribed dosage.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. Cardiovascular disorder, unstable angina pectoris, angina pectoris during sexual intercourse, arrhythmia, hypotension, hypertension, myocardial infarction within the last 3 months, cerebral infarction/cerebral hemorrhage within the last 6 months If you have liver disorder or retinitis pigmentosa.
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• Usual dosage： In general, for adults, take 10 mg of the active ingredient once a day about 1 hour before sexual activity.If the effect is insufficient and it is judged to be well tolerated, take 20 mg at a time. may be increased to Allow at least 24 hours between doses.
  If you have mild or moderate liver disorder：In general, for adults, take 10 mg of the active ingredient once a day about 1 hour before sexual activity.Do not exceed this amount. Allow at least 24 hours between doses.
  If you have moderate renal disorder: If you have moderate renal disorder: In general, for adults, start with 5 mg of the active ingredient once a day, about 1 hour before sexual activity. Allow at least 24 hours between doses. The dose may be increased to a maximum of 1 tablet (10 mg), but do not exceed this amount and leave an interval of at least 48 hours between doses.
• If you have severe renal disorder: In general, for adults, take 5 mg of the active ingredient once a day about 1 hour before sexual activity.Do not exceed this amount. Allow at least 24 hours between doses. This medicine contains 20mg of the active ingredient in 1 tablet. Be sure to follow the prescribed usage method.
• Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.

Precautions in daily life

• This medicine may cause dizziness or visual disturbance (blurry vision, etc.). Pay close attention when you work at heights, drive a car or operate dangerous machinery.
• Refrain from taking grapefruit juice, as it may enhance the effects of the medicine and increase side effects.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include headache, flushing, hot flush, indigestion, back pain, muscle pain, nasal congestion and limb pain . If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• rash, swelling of face, erosion of lips/mouth/conjunctiva [hypersensitivity]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

I fully understand the above effects and side effects. Do not take orally other than the prescribed dosage.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. I plan to have a prostate cancer screening ( PSA test).
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 0.2 mg of the active ingredient at a time, once a day. The dosage may be increased as needed , but the upper limit is 1 mg per day. This drug contains 1 mg of the main ingredient in 1 tablet. Be sure to follow the directions for use.
• If you miss a dose, take the missed dose for the day when you remember. Do not take 2 doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions in daily life

• Do not split or crush. [The pharmacological action (dihydrotestosterone lowering action) of this drug may affect the normal development of male fetal reproductive organs.]

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include decreased libido and weak erection of the penis. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• loss of appetite, general malaise, yellowing of skin and mucous membranes [liver dysfunction]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away. Please consult the pharmacy or medical institution where you received the product regarding disposal.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. I plan to have a prostate cancer screening ( PSA test). If you have liver dysfunction.
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for male adults, take 1 capsule (0.5 mg of the active ingredient) at a time, once a day. If necessary, the capsule containing 0.1mg of the active ingredient in 1 capsule may be switched to 1 capsule once a day. Be sure to follow the directions for use.
• Do not chew or open the capsule as the contents of the capsule may irritate the oropharyngeal mucosa.
• If you miss a dose, take it as soon as possible when you remember. However, if it is almost time for the next dose , skip the missed dose and continue your regular dosing schedule. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions in daily life

• Women and children should not touch the drug leaked from the capsule as it is absorbed through the skin. If you come into contact with spilled chemicals, wash immediately with soap and water.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include sexual dysfunction (decreased libido, erectile dysfunction, ejaculation disorder). If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• loss of appetite, general malaise, yellowing of skin and mucous membranes [liver dysfunction, jaundice]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Keep out of reach of infants and children, avoiding direct sunlight, high temperature and humidity, and store in PTP packaging.
• If you have leftover medicine, do not store it and throw it away. Please consult the pharmacy or medical institution where you received the product regarding disposal.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, start with 10 mg of the active ingredient once a day, and after 2 weeks, take 20 mg once a day, and after 6 weeks, 40 mg once a day as a maintenance dose, while having your blood uric acid level measured. The dose is gradually increased as needed. The dosage may be adjusted according to the condition, but the maximum dosage is 60 mg once a day. This drug contains 20mg of the active ingredient in 1 tablet.
• Be sure to follow the directions for use.
• If you miss a dose, take the missed dose as soon as possible when you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take 2 doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include gouty arthritis, arthralgia, limb discomfort, limb pain, diarrhea and malaise. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• general malaise, loss of appetite, yellowing of skin and whites of eyes [liver dysfunction]
• rash or rash all over the body [hypersensitivity]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have high blood potassium level, before surgery, on hemodialysis, on low salt therapy, renal disorder, liver disorder, cerebrovascular disorder.
• Pregnant, possibly pregnant, breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• Adults: In general, take 20 mg of the active ingredient at a time, once a day. The dosage may be adjusted according to your age and symptoms, but the maximum daily dose is 40 mg.
• If you miss a dose, take the missed dose when you remember. However, please wait at least 8 hours before taking the next dose. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions in daily life

• This medicine may cause dizziness or lightheadedness due to excessively lowered blood pressure. Pay close attention when working at heights or operating dangerous machinery such as driving a car.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include rash, eczema, itch, dizziness, headache and diarrhea. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• swelling of face/tongue/throat, breathing difficulty [angioedema]
• feeling cold, vomiting, loss of consciousness [shock, fainting, loss of consciousness]
• decreased urine output, swelling of face/limbs, fever [acute kidney injury]
• numbness of limbs and lips, muscle weakness [hyperkalemia]
• general malaise, loss of appetite, yellowing of skin and whites of eyes [liver dysfunction]
• muscle pain, weakness, reddish brown urine [rhabdomyolysis]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously had allergic symptoms such as itching or rash to medicines or foods. If you have liver disorder or renal disorder.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• Gastric/duodenal ulcer, reflux esophagitis：In general, for adults, take 2 tablets (20 mg of vonoprazan) at a time, once a day. The duration of use is up to 8 weeks for gastric ulcer and up to 6 weeks for duodenal ulcer. For reflux esophagitis, it is usually taken for up to 4 weeks, but if the effect is insufficient, it may be taken for up to 8 weeks.
  Maintenance therapy for reflux esophagitis with repeated relapses and flares： In general, for adults, take 1 tablet (10 mg of vonoprazan) at a time, once a day.If the effect is insufficient, take 2 tablets (20 mg) at a time. may be increased to Be sure to follow the prescribed usage method.
• If you miss a dose, take the missed dose when you remember. However, wait at least 8 hours before taking the next dose. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include constipation, diarrhea, abdominal bloating, nausea, rash and swelling. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• feeling sick, sweating, breathing difficulty, rash, facial swelling, convulsion [shock, anaphylaxis]
• general malaise, fever, shortness of breath, nosebleed/subcutaneous bleeding [pancytopenia, agranulocytosis, decreased white blood cell, decreased platelets]
• general malaise, loss of appetite, yellowing of skin and whites of eyes [liver dysfunction]
• fever, general malaise, rash/reddening of skin/eyes/mouth [toxic epidermal necrolysis, mucocutaneous-ocular syndrome, erythema multiforme]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have liver disorder or diabetes.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 1 tablet (10 mg of the active ingredient) at a time, once a day after a meal, but the dose may be adjusted according to your age and symptoms. Be sure to follow the directions for use.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose. Never take two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include constipation, rash, diarrhea, abdominal pain, enlarged abdomen and nausea/vomiting. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• breathing difficulty, swelling of eyelids/lips/tongue/pharynx, rash [hypersensitivity]
• muscle pain, weakness of limbs, reddish brown urine [rhabdomyolysis]
• general malaise, loss of appetite, nausea/vomiting [liver dysfunction]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have bleeding (hemophilia, capillary fragility, urinary tract bleeding, gastrointestinal ulcer, hemoptysis, vitreous hemorrhage, etc.). I am scheduled for surgery.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, take 1 sachet at a time, once a day immediately after meals. The amount will be increased according to the triglyceride level, but the upper limit is 1 sachet at a time, twice a day. Be sure to follow the directions for use.
• If taken on an empty stomach, it will be poorly absorbed, so take it immediately after meals.
• Take without chewing.
• If you miss a dose, skip the missed dose and continue your regular dosing schedule. Never take two doses at once
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop taking this medicine on your own without a doctor's order.

Precautions in daily life

• Please adhere to the prescribed diet and exercise regimen.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include diarrhea, rash and itch. If you notice any of these symptoms, consult your doctor or pharmacist.
The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away.

The following people may need attention. Be sure to tell your doctor or pharmacist.

• If you have previously experienced allergic symptoms such as itching or rashes to medicines or foods. If you have a history of epilepsy or convulsions. If you have renal dysfunction, renal tubular acidosis, urinary tract infection or liver dysfunction.
• pregnant or breastfeeding
• If you are using other medicines, etc. (Please be careful, including other over-the-counter medicines and foods that you are currently using, as they may strengthen or weaken each other's effects.)

Dosage and administration (how to use this medicine)

• In general, for adults, start with 5 mg of the active ingredient once a day, increase by 5 mg every week, and increase to 20 mg once a day from the 4th week. This drug contains 20mg of the main ingredient in one tablet. Be sure to follow the directions for use.
• This medicine disintegrates when it is placed on the tongue and soaked with saliva, so it can be taken without water. You can also drink it with water. Do not give without water while lying down.
• If you miss a dose, give the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and give the next dose at the scheduled time. Never give two doses at once.
• If you accidentally take too much, consult your doctor or pharmacist.
• Do not stop giving this medicine on your own judgment without your doctor's instructions.

Precautions in daily life

• Please note that dizziness may occur in the initial period of administration.
• Moderate and severe Alzheimer's disease may impair the ability to operate dangerous machinery, such as driving a car. In addition, this medicine may cause drowsiness and dizziness.Do not allow the patient to operate dangerous machinery such as driving a car.

Precautions after using this medicine (side effects)

The most commonly reported adverse reactions include dizziness, constipation, weight loss, headache, loss of appetite, increased blood pressure, fall, edema, abnormal gait and hallucination. If you notice any of these symptoms, consult your doctor or pharmacist.
In rare cases, the following symptoms may occur, which may be the initial symptoms of the side effects shown in [ ]. In such cases, discontinue use and seek medical attention immediately.

• spasmodic muscle contraction [convulsion]
• fainting [fainting, loss of consciousness]
• violently raised emotions or voice, unfounded subjective beliefs that attack and hurt self or others [psychiatric symptoms (agitation, aggression, delusions, hallucinations, confusion, delirium)]
• general malaise, loss of appetite, yellowing of skin and whites of eyes [liver dysfunction, jaundice]
• muscle pain, weakness, reddish brown urine [rhabdomyolysis]
• shortness of breath, dizziness, faint [bradyarrhythmia such as complete atrioventricular block, severe sinus bradycardia]

The above side effects are not all-inclusive. If you have any symptoms other than those listed above, consult your doctor or pharmacist.

Storage method and others

• Store out of reach of infants and children, avoiding direct sunlight, high temperature and humidity.
• If you have leftover medicine, do not store it and throw it away. Please consult the pharmacy or medical institution where you received the product regarding disposal.